Name: Wei Hongjiang
Professional title: Professor
Research focus: Basic Veterinary Medicine
Tutor category: RPhD Supervisor £Master Supervisor £Neither
E-mail address: hongjiangwei@126.com
Education
Apl 2001 - Mar 2004, Kagoshima University, Science of animal production, Doctor of Agriculture
Apl 1998 - Mar 2001, Kagoshima University, Science of animal production, Master of Agriculture
Apl 1996 - Mar 1997, Kagoshima University, Science of animal production, International exchange student
Sep 1992- Jul 1996, Yunnan Agricultural University, Science of animal husbandry, Bachelor of Agriculture
Career
Nov 2011 - now, Yunnan Agricultural University, Professor
Sep 2006 - Nov 2011, Yunnan Agricultural University, Associate Professor
Nov 2004 - Sep 2006, Yunnan Agricultural University, Lecturer
Jul 1996 - Mar 1998, Yunnan Agricultural University, Teaching Assistant
Courses
Veterinary Obstetrics
Research focus
1.Animal gene editing and somatic cell nuclear transfer
2.Xenotransplantation
Research & Teaching
Research projects
1. National Key Research and Development Program, 2019YFA0100700, Construction and preclinical study of human gene-edited donor pigs for xenotransplantation, Sep 2019 - Dec 2023, 27.71 million, in charge
2. National Natural Science Foundation of China, Regional Science Foundation Project, 31560637, Molecular Mechanism of developmental death and abnormality in parthenogenetic mammals and its implications for animal sexual reproduction and human genetic disease genes, Jan 2016 - Dec 2019, 400 thousands, in charge
3. Major Science and Technology Plan of Yunnan Province, Construction of miniature pig model and platform for major human diseases, Jul 2021 - Jun 2024, 60 million, in charge
4. Major Science and Technology Plan of Yunnan Province, Innovation and application of key techniques for porcine non-human primate xenotransplantation, Jan 2021 - Dec 2023, 12.5 million, in charge
Teaching projects
Yunnan Agricultural University, Teaching reform project, 2017YAUJY012, Scientific research promotes teaching and highlights the characteristics of the course 《Introduction to Animal Production》, Jul 2017 - Jul 2019, 5 thousands, in charge
Representative achievements
Journal Publications
[1]Heng Zhao#, Weijian Ye#, Jianxiong Guo#, Jiaoxiang Wang, Deling Jiao, Kaixiang Xu, Chang Yang, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Jie Cai, Tien Dat Nguyen1, Yubo Qing, Wenmin Cheng, Baoyu Jia, Honghui Li, Hong-Ye Zhao*, Qingfeng Chen*, Hong-Jiang Wei*. Development of RAG2-/-IL2Rg-/Y immune deficient FAH-knockout miniature pig. Frontiers in Immunology. 2022. (IF=8.786).
[2]Kaixiang Xu #, Wanyun Zhu #, Anyong Xu #, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei*, Hong-Ye Zhao*. Inhibition of FOXO1-mediated autophagy promotes paclitaxel-induced apoptosis of MDA-MB-231 cells. Molecular Medicine Reports. 2022, 25(2):72. (IF=3.432)
[3] Jing Wang #, Sami Ullah Khan #, Pan Cao #, Xi Chen, Fengchong Wang, Di Zou, Honghui Li, Heng Zhao, Kaixiang Xu, Deling Jiao, Chang Yang, Feiyan Zhu, Yaxuan Zhang, Yanhua Su, Wenmin Cheng, Baoyu Jia, Yubo Qing, Muhammad Ameen Jamal, Hong-Ye Zhao*, Hong-Jiang Wei*. Construction of PIK3C3 transgenic pig and its pathogenesis of liver damage. Life (Basel). 2022, 24;12(5):630. (IF=3.251)
[4] Jilong Ren #, Dawei Yu#, Jing Wang#, Kai Xu#, Yanan Xu, Renren Sun, Peipei An, Chongyang Li, Guihai Feng, Ying Zhang, Xiangpeng Dai, Hongye Zhao, Zhengzhu Wang, Zhiqiang Han, Haibo Zhu, Yuchun Ding, Xiaoyan You, Xueqin Liu, Meng Wu,Lin Luo, Ziyi Li, Yong‑Guang Yang, Zheng Hu*, Hong-Jiang Wei*, Liangpeng Ge*,Tang Hai*, Wei Li*. Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver. Cell & Bioscience. 2022, 12(1):26. (IF=9.584).
[5] Yubo Qing #, Muhammad Ameen Jamal #, Dejia Shi, Sumei Zhao, Kaixiang Xu, Deling Jiao, Heng Zhao, Honghui Li, Baoyu Jia, Haizhen Wang, Hong-Ye Zhao*, Hong-Jiang Wei*. Delayed body development with reduced triglycerides levels in leptin transgenic pigs. Transgenic Research. 2022, 31(1):59-72. (IF=3.145)
[6] Kaixiang Xu #, Honghao Yu #, Shuhan Chen #, Yaxuan Zhang #, Jianxiong Guo, Chang Yang, Deling Jiao, Tien Dat Nguyen, Heng Zhao, Jiaoxiang Wang, Taiyun Wei, Honghui Li, Baoyu Jia, Muhammad Ameen Jamal, Hong-Ye Zhao*, Xingxu Huang*, Hong-Jiang Wei*. Production of triple-gene (GGTA1, B2M and CIITA)-modified donor pigs for xenotransplantation. Frontiers in Veterinary Science. 2022, 9:848833. (IF=3.471)
[7] Tien Dat Nguyen #, Honghui Li #, Yiquan Zhuang, Bowei Chen, Keiji Kinoshita, Muhammad Ameen Jamal, Kaixiang Xu, Jianxiong Guo, Deling Jiao, Kumiko Tanabe, Yunfang Wei, Zhuo Li, Wenming Cheng, Yubo Qing, Hong-Ye Zhao*, Hong-Jiang Wei*. In vitro and in vivo development of interspecies Asian elephant embryos reconstructed with pig enucleated oocytes. Animal Biotechnology. 2022, 11:1-10. (IF=2.141)
[8] Muhammad Ameen Jamal #, Samiullah Khan #, Yanhua Su, Chang Yang, Heng Zhao, Kaixiang Xu, Deling Jiao, Wenmin Cheng, Abdul Rauf, Mahboob Ali, Sohail Ahmad, Yubo Qing*, Hong-Jiang Wei*. Small ruminant farming in tribal areas of Dera Ghazi Khan, Punjab, Pakistan. Veterinary Sciences. 2022, 7;9(6):279. (IF=2.518)
[9] Yanan Yue #, Weihong Xu #, Yinan Kan #, Hong-Ye Zhao #, Yixuan Zhou #, Xiaobin Song #, Jiajia Wu, Juan Xiong, Dharmendra Goswami, Meng Yang, Lydia Lamriben, Mengyuan Xu, Qi Zhang, Yu Luo, Jianxiong Guo, Shengyi Mao, Deling Jiao, Tien Dat Nguyen, Zhuo Li, Jacob V. Layer, Mailin Li, Violette Paragas, Michele E. Youd, Zhongquan Sun, Yuan Ding, Weilin Wang, Hongwei Dou, Lingling Song, Xueqiong Wang, Lei Le, Xin Fang, Haydy George, Ranjith Anand, Shi Yun Wang, William F. Westlin, Marc Güell, James Markmann, Wenning Qin*, Yangbin Gao*, Hong-Jiang Wei*, George M. Church*, Luhan Yang*. Extensive germline genome engineering in pigs. Nature Biomedical Engineering, 2021, 5(2):134-143. (IF=29.234)
[10] Deling Jiao #, Wenmin Cheng #, Xiaolin Zhang #, Yifan Zhang #, Jianxiong Guo, Zhuo Li, Dejia Shi, Zhe Xiong, Yubo Qing, Muhammad Ameen Jamal, Kaixiang Xu, Hong-Ye Zhao*, Hong-Jiang Wei*. Improving porcine SCNT efficiency by selecting donor cells size. Cell Cycle. 2021, 20(21):2264-2277. (IF=5.173)
[11]Honghui Li #, Wenmin Cheng #, Bowei Chen #, Shaoxia Pu, Ninglin Fan, Xiaolin Zhang, Deling Jiao, Dejia Shi, Jianxiong Guo, Zhuo Li, Yubo Qing, Baoyu Jia, Hong-Ye Zhao*, Hong-Jiang Wei*. Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing. Life (Basel). 2021, 11(12):1417. (IF=3.251)
[12]Heng Zhao #, Yuying Li #, Thanapa Wiriyahdamrong #, Zaimei Yuan, Yubo Qing, Honghui Li, Kaixiang Xu, Jianxiong Guo, Baoyu Jia, Xuezeng Zhang, Wenmin Cheng, Yanhua Su, Weihu Long, Jing Wang, Di Zou, Keji Kinoshita, Hong-Ye Zhao*, Hong-Jiang Wei*. Improved production of GTKO/hCD55/hCD59 triple-gene modified Diannan miniature pigs for xenotransplantation by recloning. Transgenic Research, 2020, 29(3): 369-379. (IF=2.788)
[13]Baoyu Jia #, Decai Xiang #, Jianxiong Guo, Deling Jiao, Guobo Quan, Qionghua Hong, Xiangwei Fu, Hongjiang Wei*, Guoquan Wu*. Successful vitrification of early-stage porcine cloned embryos. Cryobiology. 2020, 97:53-59. (IF=2.487)
[14]Jimin Fei#, Anyong Xu#, Wen Zeng, Yukun Liu, DelingJiao, Wanyun Zhu, Kaixiang Xu, Honghui Li, Hong-Jiang Wei*, Hong-Ye Zhao*. The molecular basis for P53 inhibition of autophagy in porcine fibroblast cells. Translational Cancer Research. 2019, 8(3): 876-886. (IF=1.241)
[15]Junjun Xu#, Leqian Yu, Jianxiong Guo, Jinzhu Xiang, Zheng Zheng, Dinging Gao, Bingbo Shi, Haiyang Hao, Deling Jiao, Liang Zhong, Yu Wang, Jun Wu, Hongjiang Wei*, Jianyong Han*. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy, 2019, 10: 193. (IF=5.116)
[16]Deling Jiao#, Zhen Yang#, Lulu Wang#, Binyue Hu, Jing Wang, Anyong Xu, Wenmin Cheng, Baoyu Jia, Yubo Qing, Hong-Ye Zhao*, Hong-Jiang Wei*. Endogenous leptin promotes autophagy in EBSS-induced PFCs. Animal Cells and Systems, 2019, 23(5): 318-325. (IF=0.907)
[17]Junchen Chen#, Weiqi Zeng#, Weirong Pan#, Cong Peng, Jianglin Zhang, Juan Su, Weihu Long, Heng Zhao, Xiaoxia Zuo, Xiaoyun Xie, Jing Wu, Ling Nie, Hongye Zhao, Hong-jiang Wei*, Xiang Chen*. Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs. PLoS Biology, 2018, 16(8): e2005354. (IF=8.386)
[18]Fengjuan Liu#, Jinji Liu#, Zaimei Yuan, Yubo Qing, Honghui Li, Kaixiang Xu, Wanyun Zhu, Heng Zhao, Baoyu Jia, Weirong Pan, Jianxiong Guo, Xuezen Zhang, Wenmin Cheng, Wei Wang*, Hong-Ye Zhao*, Hong-Jiang Wei*. Generation of GTKO Diannan miniature pig expressing human complementary regulator proteins hCD55 and hCD59 via T2A peptide-based bicistronic vectors and SCNT. Molecular Biotechnology, 2018, 60(8): 550-562. (IF=1.712)
[19]Honghao Yu#, Weihu Long#, Xuezeng Zhang#, Kaixiang Xu, Jianxiong Guo, Heng Zhao, Honghui Li, Yubo Qing,Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Xingxu Huang*, Hong-Jiang Wei*. Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. Journal of Translational Medicine, 2018, 16(1): 1-14. (IF=4.098)
[20]Wenjing Li#, Wanyun Zhu#, Chaoxiang Lv, Hao Qu, Kaixiang Xu, Honghui Li, Haifeng Li, Yiming Du, Guangming Liu, Yunyue Wang, Hong-Jiang Wei*, Hong-Ye Zhao*. Low-dose paclitaxel down-regulates c-Myc in colorectal carcinoma cells. Oncology Letters, 2018, 15: 1881-1887. (IF=1.871)
[21]Youfeng Shen#, Kaixiang Xu#, Zaimei Yuan, Jianxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Hong-Jiang Wei*. Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer. Journal of Translational Medicine, 2017, 15: 224-234. (IF=4.179)
[22]Yongzhi Yang#, Yutao Wang#, Yue Zhao#, Xiuying Zhang, Ran Li, Lei Chen, Guojie Zhang, Yu Jiang, Qiang Qiu, Wen Wang, Hong-Jiang Wei*, Kun Wang*. Draft genome of the Marco Polo Sheep (Ovis ammon polii). GigaScience, 2017, 6: 1-7. (IF=7.267)
[23]Dong Niu#, Hong-jiang Wei#, Lin Lin#, Haydy George#, Tao Wang#, I-Hsiu Lee#, Yong Wang, Yinan Kan, Ellen Shrock, Emal Lesha, Gang Wang, Yonglun Luo, Yubo Qing, Deling Jiao, Heng Zhao, Hongye Zhao, Xiaoyang Zhou, Shouqi Wang, Hong Wei, Marc Guell*, George M. Church*, Luhan Yang*. Inactivation of porcine endogenous retrovirus activity in pigs using CRISPR-Cas9. Science, 2017, 357: 1303-1307. (IF=41.058)
[24]Yun-Fang Wei#, Jiu-Sheng Wan#, Fang-Liang Chen, Chao Chen, Jing Li, Lu-Guang Cheng, Ai-Guo Mao, Fei-Xiang Li, Bin Wang, Qing-Guo Huang, Shu-Sheng Tang*, Hong-Jiang Wei*. A retrospective study of female reproductive parameters in the Kunming dog. Animal Science Journal, 2018, 89(1): 52-59. (IF=1.301)
[25]Wanyun Zhu#, Hao Qu#, Kaixiang Xu, Anyong Xu, Baoyu Jia, Haifeng Li, Yimin Du, Guangming Liu, Hong-Jiang Wei*, Hong-Ye Zhao*. Differences in the starvation-induced autophagy response in MDA-MB-231 and MCF-7 breast cancer cells. Animal Cells and Systems. 2017, 21(3): 190-198. (IF=0.544)
[26]Chaoxiang Lv#, Hao Qu#, Kaixiang Xu, Wanyun Zhu, Anyong Xu, Baoyu Jia, Yubo Qing, Honghui Li, Hong-Jiang Wei*, Hong-Ye Zhao*. Low-dose paclitaxel inhibits tumor cell growth by regulating glutaminolysis in colorectal carcinoma cells. Frontiers in Pharmacology, 2017, 8: 244. (IF=3.831)
[27]Honghui Li#, Gui Wang#, Zhiqiang Hao#, GuoZhong Zhang, Yubo Qing, Shuanghui Liu, Lili Qing, Weirong Pan, Lei Chen, Guichun Liu, Ruoping Zhao, Baoyu Jia, Luyao Zeng, Jianxiong Guo, Lixiao Zhao, Heng Zhao, Chaoxiang Lv, Kaixiang Xu, Wenmin Cheng, Hushan Li, Hong-Ye Zhao*, Wen Wang*, Hong-Jiang Wei*. Generation of biallelic knock-out sheep via gene-editing and somatic cell nuclear transfer. Scientific Reports. 2016, 6: 33675. (IF=4.259)
[28]Honghao Yu#, Heng Zhao#, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Xingxu Huang*, Hong-Jiang Wei*. Porcine zygote injection with Cas9/sgRNA results in DMD-modified pig with muscle dystrophy. International Journal of Molecular Sciences, 2016, 17: 1668. (IF=3.257)
[29]Wenmin Cheng#, Heng Zhao#, Honghao Yu, Jige Xin, Jia Wang, Luyao Zeng, Zaimei Yuan, Yubo Qing, Honghui Li, Baoyu Jia, Cejun Yang, Youfeng Shen, Lu Zhao，Weirong Pan, Hong-Ye Zhao*,Wei Wang*, Hong-Jiang Wei*. Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer. Reproductive biology and Endocrinology, 2016,14(1): 77. (IF=2.147)
[30]Weirong Pan#, Guozhong Zhang#, Yubo Qing, Honghui Li, Wenmin Cheng, Xin Wang, Xiaobing Li, Yingchao Liu, Jia Wang, Liangxue Lai, Hong-Ye Zhao*, Hong-Jiang Wei*. Evaluation of cloning efficiency based on the production of cloned Diannan miniature pigs. Research & Reviews: Journal of microbiology and biotechnology, 2015, 4: 1-8.
[31]Yubo Qing#, Wenmin Cheng#, Yingchao Liu, Xiaobing Li, Weirong Pan, Honghui Li, Si Li, Baoyu Jia, Hongye Zhao*, Hong-Jiang Wei*. Development before and after cryopreservation of porcine parthenogenetic embryos derived from early-delipated oocytes. Research & Reviews: Journal microbiology and biotechnology, 2015, 4: 47-54.
[32]Hongjiang Wei*, Yubo Qing, Weirong Pan, Hongye Zhao, Honghui Li, Wenmin Cheng, Lu Zhao, Chengsheng Xu, Hong Li, Si Li, Lei Ye, Taiyun Wei, Xiaobing Li, Guowen Fu, Wengui Li, Jige Xin, Yangzhi Zeng. Comparison of the efficiency of Banna miniature inbred pig somatic cell nuclear transfer among different donor cells. PLoS One, 2013, 8(2): e57728. (IF: 4.092).