Name：Xiaobing Li
Professional title：Professor
Acidemic Title:
1. President, Branch of Veterinary Imaging Technology, Chinese Society of Animal Husbandry and Veterinary Medicine (CAAV)
2. Academic adviser, Branch of Veterinary Internal Medicine and Clinical Medicine, Chinese Society of Animal Husbandry and Veterinary Medicine (CAAV)
Research focus：Clinical Veterinary Medicine
Tutor category：RPhD Supervisor £Master Supervisor £Neither
E-mail address：xiaobingli@yeah.net,
Education
Sep 1991 - Jul 1996, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Bachelor.
Sep 1996 - Jul 1999, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Master.
Sep 2001 - Jul 2005, Jilin University, College of Veterinary Medicine, Ph.D.
Career
Jul 1999-Jul 2001, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Teaching Assistant.
Jul 2001-Sep 2008, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Lecturer.
Sep 2008-Oct 2011, Jilin University, College of Veterinay Medicine, Associate Professor.
Oct 2011-Jan 2020, Jilin University, College of Veterinay Medicine, Professor.
Jan 2020-now, Yunnan Agricultural University, College of Veterinary Medicine, Professor.
Courses
1. Veterinary Imaging
2. Veterinary Clinical Diagnosis
3. Animal Nutritional and Metabolic Diseases
4. Special topics in Veterinary Imaging
Research focus
1. Nutritional & metabolic diseases and toxonosis of ruminants
2. Veterinary imaging diagnostic technique
Research & Teaching
Research projects
1. National Natural Science Foundation of China, Regional Science Foundation Project, 32360904, The role and mechanism of bta-miR-27b in liver injury of dairy cows with fatty liver by targeting Nrf2 to regulate pyroptosis, from 2024-01 to 2027-12, 320 thousands, finished, in charge.
1. Science and Technology Department of Yunnan Province, Basic Research Special Project - key project, 202101AS070296, Study on the Mechanism of IFN-τ regulating the Inflammatory injury of endometrial epithelial cells of Dairy Cows through bta-miR-200b/PI3K/ AKT signaling axis, 2022-06 to 2025-05, 500 thousands, finished, in charge.
2. National Natural Science Foundation of China, Regional Science Foundation Project, 32060818, The regulatory role of Nrf2 in the lipid metabolism disorder in the adipose tissue of dairy cows with ketosis, from 2021-01 to 2024-12, 350 thousands, finished, in charge.
3. National Natural Science Foundation of China, general project, 31872536, Regulatory mechanism of Perilipin1 on lipid homeostasis and inflammatory pathway in adipose tissue of ketotic dairy cows, from 2019-01 to 2022-12, 590 thousands, finished, in charge.
4. National Natural Science Foundation of China, general project, 31572581,The effects of high-level NEFA on the lipid metabolism and secretion of adipose tissue in perinatal dairy cows, from 2016-01 to 2019-12, 640 thousands, finished, in charge.
5. National Natural Science Foundation of China, general project, 31272621, AMPK signal transmission mechanism of lipid metabolic disorder in liver of dairy cows with ketosis, from 2013-01 to 2016-12, 810 thousands, finished, in charge.
6. National Natural Science Foundation of China, general project, 30972224, Effect of PTEN and SREBP-1c Gene Regulation on Fatty Deposition in Hepatocyte of Dairy Cows, from 2010-01 to 2012-12, 310 thousands, finished, in charge.
7. National Natural Science Foundation of China, Special Fund Projects, 30640049, Apolipoprotein B100 and E Mechanism of Action on Dairy Cows Fatty Liver Development, from 2007-01 to 2007-12,100 thousands, finished, in charge.
8. Ministry of Science and Technology of the People’s Republic of China, Grants from National Key R&D Program of China, 2016YFD0501007-8, Research on imaging diagnostic technology and prevention & control products of liver and gallbladder diseases in dogs and cats, from 2016.07 to 2020.12, 770 thousands, finished, in charge.
9. Ministry of Science and Technology of the People’s Republic of China, The National High Technology Research and Development Program of China (863 project), 2007AA10Z426, Development of rapid immunological detection technology for four mycotoxins in agricultural products, from 2007-01 to 2010-10, 500 thousands, finished, in charge.
Awards & Honors
1. Li Xiaobing (3/6) Molecular mechanism of liver injury caused by hepatic lipid metabolism disorder in dairy cows with ketosis，Science and Technology Department of Jilin Province, First prize of Science and Technology Award of Jilin Province, 2020 (Liu Guowen, Li Xinwei, Li Xiaobing, Wang Zhe, Du Xiliang, Song Yuxiang).
2. Li Xiaobing (3/8) Mechanism of high-level NEFA and BHBA on liver lipotoxicity of Ketosis Dairy cows, Science and Technology Department of Jilin Province，Jilin Province natural science academic achievement Award second prize, 2015（Liu Guowen, Li Xinwei, Li Xiaobing, Wang Zhe, Wang Jianguo, Liu Lei, Li Yu, Den Qinghua）.
3. Li Xiaobing (3/15) Molecular mechanism and prevention of ketosis in dairy cows，Science and Technology Department of Jilin Province，First prize of Science and technology progress of Jilin Province, 2010 (Wang Zhe, Liu Guowen, Li Xiaobing, Xv Chuang, Zhang Zhigang, Zhang Naisheng, Chen Chengzhen, Li Yangfei, Xia Cheng, Zhang Cai, Zhang Hui, Yang Wenyan, Niu Shuling, Zhang Yonghong, Xie Guanghong).
Representative achievements
Journal Publications
[1] Fan M#, Du X, Chen X, Bai H, Loor JJ, Shen T, Liang Y, Sun X, Xu Q, Song Y, Wang Z, Liu G, Yang L, Li X, Li X*, Gao W*. Inhibition of cell death inducing DNA fragmentation factor-α-like effector c (CIDEC) by tumor necrosis factor-α induces lipolysis and inflammation in calf adipocytes. Journal of Dairy Science. 2021 May; 104(5): 6134-6145.
[2] Qiushi Xu#, Hongdou Jia, Li Ma, Guowen Liu, Chuang Xu, Ying Li, Xinwei Li* and Xiaobing Li*. All-trans retinoic acid inhibits lipopolysaccharide-induced inflammatory responses in bovine adipocytes via TGFβ1/ Smad3 signaling pathway[J]. BMC Veterinary Research. 2019 Feb 1; 15(1): 48.
[3] Hongdou Jia#, Xiaobing Li#, Guowen Liu, Juan J. Loor, Ryan Buctrout, Xudong Sun, Guojin Li, Xin Shu, Jihong Dong, Yazhe Wang, Rankun Zuo, Zhe Wang, Xinwei Li*. Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very-low-density lipoprotein assembly[J]. J Dairy Sci. 2019 Jan; 102(1): 833-845.
[4] Shiqi Zhang#, Guowen Liu#, Chuang Xu#, Lei Liu, Qiang Zhang, Qiushi Xu, Hongdou Jia, Xiaobing Li*, Xinwei Li*. Perilipin 1 Mediates lipid Metabolism homeostasis and inhibits inflammatory cytokine synthesis in Bovine adipocytes[J]. Front Immunol. 2018 Mar 9; 9: 467.
[5] Xin-Wei Li#, Qiu-Shi Xu#, Ren-He Zhang, Wei Yang, Yu Li, Yu-Ming Zhang, Yu Tian, Min Zhang, Zhe Wang, Guo-wen Liu, Cheng Xia and Xiao-Bing Li*. Ultrasonographic findings in cows with left displacement of abomasum, before and after reposition surgery[J]. BMC Vet Res. 2018 Feb 12; 14(1): 44.
[6] Li XW#, Li Y, Ding HY, Dong JH, Zhang RH, Huang D, Lei L, Wang Z, Liu GW, Li XB*. Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows[J]. Journal of Dairy Research. 2018 May; 85(2): 157-162.
[7] Xinwei Li# , Yu Li# , Wentao Yang, Chong Xiao, Shixin Fu, Qinghua Deng, Hongyan Ding, Zhe Wang, Guowen Liu*, Xiaobing Li*. SREBP-1c overexpression induces triglycerides accumulation throughincreasing lipid synthesis and decreasing lipid oxidation and VLDLassembly in bovine hepatocytes[J]. J Steroid Biochem Mol Biol. 2014 Sep; 143: 174-182.
[8] Qinghua Deng# , Xinwei Li# , Shixin Fu, Liheng Yin, Yuming Zhang, Tingting Wang, Jianguo Wang, Lei Liu, Xu Yuan, Guoquan Sun, Zhe Wang, Guowen Liu*, Xiaobing Li*. SREBP-1c Gene Silencing can Decrease Lipid Deposits in Bovine Hepatocytes Cultured in Vitro[J]. Cell Physiol Biochem. 2014; 33(5): 1568-1578.
[9] Yan-Song Li#, Yu Zhou#, Shi-Ying Lu, De-Jun Guo, Hong-Lin Ren, Xian-Mei Meng, Bai-Hui Zhi, Chao Lin, Zhe Wang, Xiao-Bing Li*, Zeng-Shan Liu*. Development of a one-step test strip for rapid screening of fumonisins B1, B2 and B3 in maize[J]. Food Control, 2012, 24(1-2): 72-77.
[10] Shixin Fu#, Qinghua Deng, Wengtao Yang, Hongyan Ding, Xiaoxu Wang, Peng Li, Xinwei Li, Zhe Wang, Xiaobing Li*, Guowen Liu*. Increase of Fatty Acid Oxidation and VLDL Assembly and Secretion Overexpression of PTEN in Cultured Hepatocytes of Newborn Calf[J]. Cell Physiol Biochem. 2012; 30(4): 1005-1013.
Published books
1. 邓干臻主编, 李小兵、徐世文、谢富强等副主编, 小动物CT与MRI图谱（第一章 头颈部）, 辽宁科学技术出版社, 560千字, 2021.
2. 王哲、姜玉富主编, 朱连勤、刘国文、李小兵等副主编, 兽医诊断学（第三篇 影像诊断）, 科学出版社, 760千字,2010.
3. 谢富强主编，邓干臻、熊惠军、李小兵等参编, 兽医影像学（第三章 X线技术部分内容）, 中国农业大学出版社, 400千字, 2018.
4. 邓干臻主编，王凯、杨自军、李小兵等参编, 兽医临床诊断学（第十三章 X线检查部分：第一节 X线成像，第二节 呼吸X线检查）, 高等教育出版社, 545千字, 2017.
5. 张仲秋、丁伯良主编，田文儒、刘宗平、李小兵等参译, 墨克兽医手册（第十二章 呼吸系统）, 中国农业出版社, 4112千字, 2015.
6．谢富强主编，邓干臻、熊惠军、李小兵等参编,兽医影像学（第三章 X线技术部分内容）, 中国农业大学出版社, 400千字, 2011.
7．张乃生、李毓义主编, 王哲、刘国文、李小兵等参编, 动物普通病学（第二篇 呼吸系统疾病）, 中国农业出版社, 2363千字, 2011.
8．邓干臻主编, 王凯、杨自军、李小兵等参编, 兽医临床诊断学（第十三章 X线检查部分：第一节 X线成像，第二节 呼吸X线检查）, 高等教育出版社, 500千字, 2009, 参编.
9．谢富强主编, 邓干臻、熊惠军、李小兵等参编, 兽医影像学（第三章 X线技术部分内容）, 中国农业大学出版社, 400千字, 2004.
Patents
1. Li Xiaobing, Li Sunhuo, Bai Hongxu et al., Abdominal ultrasound exercise model and its pathological model, 2021-8-3, China, ZL 201910466629.8.
2. Li Xiaobing, Liu Guowen, Yang Wei et al., One invention relates to colloidal gold immuno-chromatographic test strip of silver dye enhancement technology and a preparation method, 2013-9-4, China, ZL 201010565942.6.
3. Li Xiaobing, Ouyang Huilin, Li Sunhuo et al., A restraint device for radiography of animals, 2020-11-10, China, ZL 202020076103.7.
4. Li Xiaobing, Ouyang Huilin, Li Sunhuo et al., A echocardiography restraint bed for animals, 2020-9-16, China, ZL 201921888618.0.
5. Li Xiaobing, Li Sunhuo, Ouyang Huilin et al., A cassette holder for horizontal X-ray radiography in animals. 2019-8-23, China, ZL 201821640350.4.
Words for students
Every man has his price.
Confidence in yourself is the first step on the road to success.
It’s never too old to learn.